Description
Product Characteristics:
Aliases: 2ABB_HUMAN antibody, B55 beta antibody, Beta isoform of regulatory subunit B55 protein phosphatase 2 antibody, MGC24888 antibody, PP2A B55beta antibody, PP2A PR55B antibody, PP2A subunit B B beta isoform antibody, PP2A subunit B B55 beta isoform antibody, PP2A subunit B isoform B55 beta antibody, PP2A subunit B isoform B55-beta antibody, PP2A subunit B isoform beta antibody, PP2A subunit B isoform PR55 beta antibody, PP2A subunit B isoform PR55-beta antibody, PP2A subunit B isoform R2 beta antibody, PP2A subunit B isoform R2-beta antibody, PP2A subunit B PR55 beta isoform antibody, PP2A subunit B R2 beta isoform antibody, Ppp2r2b antibody, PR2AB beta antibody, PR2AB55 beta antibody, PR2APR55 beta antibody, PR52B antibody, PR55 beta antibody, Protein phosphatase 2 (formerly 2A) regulatory subunit B (PR 52) beta isoform antibody, Protein phosphatase 2 (formerly 2A) regulatory subunit B beta isoform antibody, Protein phosphatase 2 regulatory subunit B antibody, Protein phosphatase 2 regulatory subunit B beta isoform antibody, SCA 12 antibody, SCA12 antibody, Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform antibody, Serine/threonine protein phosphatase 2A neuronal isoform antibody, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform antibody
Target Information: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq, Jul 2008]